Remimazolam Versus Midazolam for General Anesthesia Induction in Elderly Patients Undergoing Non-Cardiac Su…
This prospective watch-and-measure (no experimental treatment required) cohort study evaluates the effectiveness and safety of two benzodiazepine sedatives-remimazolam and midazolam-used for general anesthesia induction in elderly patients (≥65 years) undergoing elective non-cardiac surgery. Elderly patients have reduced organ reserve and altered pharmacokinetics/pharmacodynamics, increasing their susceptibility to anesthesia-related complications such as intraoperative hypotension, delayed emergence, and postoperative delirium.
Official registry: https://clinicaltrials.gov/study/NCT07746505 · Second Affiliated Hospital, Zhejiang University, School of Medicine · enrollment listed as 1,000
What this phase means
This is an observational study. You are not assigned a new experimental drug. Researchers measure what already happens in your care or in daily life.
Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.
What the registry says happens
This listing is observational (StudyType). The registry does not assign a new experimental drug as the study intervention.
They plan to enroll about 1,000 people at Hangzhou. Taking part typically means study visits and measurements plus check-ins.
Official title (unrewritten)
Effectiveness and Safety of Remimazolam Compared With Midazolam for General Anesthesia Induction in Elderly Patients Undergoing Non-Cardiac Surgery: A Prospective Observational Cohort Study
Primary outcome (registry wording): Intraoperative Hypotension Burden Measured by the Time-Weighted Average of Mean Arterial Pressure (TWA-MAP) Below an Absolute Threshold (<65 mmHg) or a Relative Threshold (>20% Decrease From Baseline)
Who it is for (from inclusion criteria)
- Ages 65 Years to any
- Age 65 years or older
- Scheduled for elective non-cardiac surgery under general anesthesia
- American Society of Anesthesiologists physical status I to IV
- Planned airway management with tracheal intubation or a laryngeal mask airway
Who the registry excludes
- Long-term preoperative benzodiazepine use
- Known allergy or contraindication to benzodiazepines, flumazenil, opioids, naloxone, or related drugs
- History of drug abuse or alcoholism within the past 2 years
- No preoperative cognitive assessment available
- Preoperative cognitive impairment, defined as a Mini-Mental State 6.Examination score less than 18
Public study contact (from the registry)
min Yan, doctor
Published on ClinicalTrials.gov. Contact them as a possible participant. They decide eligibility.
Sites listed on ClinicalTrials.gov
1 listed- The Second Affiliated Hospital of Zhejiang University School of Medicin — Hangzhou, China (recruiting)
FAQ about this NCT record
Is NCT07746505 still recruiting?
The sponsor posted status “Recruiting” on ClinicalTrials.gov at last ingest. Sites can pause independently. Confirm with the official record and the listed contact.
What phase is NCT07746505?
Not a traditional drug phase. Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.
Can PlainTrials tell me if I qualify for NCT07746505?
No. The inclusion and exclusion lists on this page are readable extracts of the public eligibility block. Only the study team can screen you.
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