Integrated PET/MR Assessment of Brain Recovery After Recanalization of Non-Acute Atherosclerotic MCA Occlusion
Restoration of arterial patency following recanalization of non-acute atherosclerotic middle cerebral artery (MCA) occlusion may improve cerebral blood supply. However, the extent to which restored perfusion is accompanied by changes in cerebral metabolism and functional brain network organization remains incompletely understood.
Official registry: https://clinicaltrials.gov/study/NCT07927569 · Qianfoshan Hospital · enrollment listed as 15
What this phase means
This is an observational study. You are not assigned a new experimental drug. Researchers measure what already happens in your care or in daily life.
Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.
What the registry says happens
This listing is observational (StudyType). The registry does not assign a new experimental drug as the study intervention.
They plan to enroll about 15 people at Jinan. Taking part typically means study visits and measurements plus check-ins.
Official title (unrewritten)
RESTORE: A Prospective Observational Study of Perfusion-Metabolism Recoupling and Functional Network Recovery After Recanalization of Non-Acute Atherosclerotic Middle Cerebral Artery Occlusion Using Integrated PET/MR
Primary outcome (registry wording): Change in Perfusion-Metabolism Abnormality Burden in the Affected Hemisphere From Baseline to 1 Month After Recanalization (ΔPMB)
Who it is for (from inclusion criteria)
- Ages 18 Years to 80 Years
- Aged 18-80 years, regardless of sex
- Symptomatic non-acute middle cerebral artery (MCA) occlusion, with an interval of ≥4 weeks between the most recent ischemic event or imaging confirmation of occlusion and the recanalization procedure
- Occlusion involving the M1 segment of the MCA, confirmed by computed tomography angiography (CTA), magnetic resonance angiography (MRA), or digital subtraction angiography (DSA)
- Occlusion presumed to be of atherosclerotic origin
- Preoperative PET/MR images of sufficient quality for quantitative analysis
- Clinically scheduled to undergo endovascular recanalization
Who the registry excludes
- Acute large-territory cerebral infarction involving more than one-third of the MCA territory
- Extensive encephalomalacia within the affected vascular territory that precludes reliable assessment of cortical regions of interest (ROIs)
- Non-atherosclerotic causes of MCA occlusion, including moyamoya disease, arterial dissection, central nervous system vasculitis, or cardioembolism
- Severe bilateral intracranial arterial occlusive disease that precludes reliable calculation of hemispheric asymmetry indices
- Structural lesions involving the cerebellum or brainstem that may interfere with metabolic analysis using the cerebellum as a reference region
- Contraindications to MRI (e.g., incompatible cardiac pacemakers, metallic foreign bodies, or severe claustrophobia) or PET imaging
- Severe head motion or imaging artifacts that render PET/MR, arterial spin labeling (ASL), or blood oxygen level-dependent (BOLD) imaging data unsuitable for analysis
Public study contact (from the registry)
Ju Han, MD
Published on ClinicalTrials.gov. Contact them as a possible participant. They decide eligibility.
Sites listed on ClinicalTrials.gov
1 listed- The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital — Jinan, Shandong, China (recruiting)
FAQ about this NCT record
Is NCT07927569 still recruiting?
The sponsor posted status “Recruiting” on ClinicalTrials.gov at last ingest. Sites can pause independently. Confirm with the official record and the listed contact.
What phase is NCT07927569?
Not a traditional drug phase. Phase labels are FDA/ICH categories applied to the registry Phase field. They are not a finding that this study succeeded.
Can PlainTrials tell me if I qualify for NCT07927569?
No. The inclusion and exclusion lists on this page are readable extracts of the public eligibility block. Only the study team can screen you.
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