PCOS trials may focus on ovulation, insulin resistance, weight, or androgen symptoms. Diagnostic criteria (Rotterdam or similar) and pregnancy plans often appear in eligibility. This is not fertility advice; it is a readable slice of public registry cards. Sourced from ClinicalTrials.gov. Not a recommendation to join any study.
RecruitingNot a traditional drug phaseNew Haven, Connecticut
Not a traditional drug phase: testing Vitamin D 4000IU daily for Polycystic Ovarian Syndrome in Adolescent FemalesThis study is a double blind, dummy treatment (placebo) controlled, randomly assigned trial of study subjects with PCOS and low vitamin D to 2 groups- dummy treatment (placebo) and vitamin D replacement. Participants and investigators will be blinded to treatment modality until the end of the trial period
NCT04355572 · Official ClinicalTrials.gov record · Yale University
RecruitingPhase 3Aurora, Colorado
Phase 3: testing Semaglutide Injectable Product (Wegovy and/or Ozempic) for PCOS (Polycystic Ovary Syndrome) of Bilateral OvariesGirls and women 12-35 years old with obesity and polycystic ovarian syndrome who are on or off metformin, will receive a glucagon like peptide-1 receptor agonist intervention for 10 months to induce metabolic changes, weight loss and improve reproductive abnormalities.
NCT05819853 · Official ClinicalTrials.gov record · University of Colorado, Denver
RecruitingNot a traditional drug phaseHouston, Texas
Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS DiagnosisThe study aims to investigate the relationship between fasting insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) across various demographic factors, including age, sex, race/ethnicity, body-mass index (BMI), and polycystic ovary syndrome (PCOS) diagnosis. By analyzing these variables, the study seeks to identify potential variations in insulin levels, which could provide valuable insights into the impact of different factors on metabolic health and the development of insulin-related conditions.
NCT05950282 · Official ClinicalTrials.gov record · Ali Chappell
RecruitingPhase 1San Francisco, California
Phase 1: testing Bicalutamide 50 mg for NAFLDNonalcoholic steatohepatitis (NASH), or fat-related liver inflammation and scarring is projected to be the leading cause of cirrhosis in the United States (U.S.) within the next few years. Women are at disproportionate risk for NASH, with approximately 15 million U.S.
NCT05979389 · Official ClinicalTrials.gov record · University of California, San Francisco
RecruitingPhase 1Karachi, Sindh
Phase 1: testing Vitamin D for Anovulatory InfertilityPoly cystic Ovarian Syndrome (PCOS) is an endocrine disorder of reproductive age defined by "the presence of any two out of three criteria: oligo and/or anovulation, excess androgen activity and/or polycystic ovarian morphology on ultrasound". Considering role of vitamin D (VD) (3, 4) and high prevalence (58%) of deficiency in PCOS of Pakistan.
NCT06045351 · Official ClinicalTrials.gov record · Aga Khan University
RecruitingPhase 1Naples, Florida
Phase 1: testing Cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for Polycystic Ovary Syndrome (PCOS)This trial will study the safety and how well it works of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells delivered intravenously for the treatment of Polycystic Ovary Syndrome.
NCT06143527 · Official ClinicalTrials.gov record · The Foundation for Orthopaedics and Regenerative Medicine
RecruitingPhase 2Philadelphia, Pennsylvania
Phase 2: testing Oral Contraceptives, Low-Dose for Metabolic SyndromeThis study will enroll women with PCOS to study the effects of first line therapy, oral contraceptive pills, and then either 12 weeks of resistant starch or 12 weeks of dummy treatment (placebo) to explore if resistant starch improves cardiometabolic parameters or impacts gut dysbiosis compared to dummy treatment (placebo).
NCT06852365 · Official ClinicalTrials.gov record · University of Pennsylvania
RecruitingNot a traditional drug phaseJacksonville, Florida
Not a traditional drug phase: testing GLP-1 Receptor Agonists for Polycystic Ovarian Syndrome in Adolescent FemalesThe prevalence of childhood obesity in the United States has more than tripled in the past four decades affecting one in every five adolescent girls and is disproportionally higher among racial and/or ethnic minorities. Normal puberty onset and progression is dependent on normal hypothalamic-pituitary-gonadal (HPG) axis which is affected by whole body metabolism.
NCT07169136 · Official ClinicalTrials.gov record · Nemours Children's Clinic
RecruitingNot a traditional drug phaseColumbus, Ohio
Not a traditional drug phase: Ketogenic diet for PCOS (Polycystic Ovary Syndrome)The SPARK- Pilot study (Symptoms of PCOS Ameliorated by Responses to Keto-adaptation) is a 12-week clinical trial at The Ohio State University designed to explore how different ways of achieving ketosis may improve reproductive and metabolic health in women with Polycystic Ovary Syndrome (PCOS). you would be randomly assigned to one of two groups: * A ketogenic diet group, following a low-carbohydrate, nutrient-dense meal plan.
NCT07227363 · Official ClinicalTrials.gov record · Ohio State University
RecruitingNot a traditional drug phaseIstanbul, Istanbul
Not a traditional drug phase: Synbiotic Supplement for PCOS (Polycystic Ovary Syndrome)This study will look at whether a reduced-calorie Mediterranean-style eating plan, together with a synbiotic supplement, can improve health measures and quality of life in women who have polycystic ovary syndrome (PCOS) and are overweight or have obesity. you would be assigned by chance (like flipping a coin) to receive either the synbiotic supplement or a dummy treatment (placebo) (a look-alike product with no active ingredients).
NCT07342946 · Official ClinicalTrials.gov record · Atlas University
RecruitingNot a traditional drug phaseCleveland, Ohio
Not a traditional drug phase: Stelo glucose biosensor by Dexcom for Polycystic Ovarian Syndrome (PCOS)This study wants to learn more about blood sugar control in polycystic ovarian syndrome. The patient will be asked to wear a continuous glucose monitor (CGM) device that is applied to the arm with a sensor or filament that goes under the skin to measure your sugar levels.
NCT07392476 · Official ClinicalTrials.gov record · The Cleveland Clinic
RecruitingNot a traditional drug phaseHanoi, Hanoi
Not a traditional drug phase: testing Progestin-Primed Ovarian Stimulation (PPOS) for Polycystic Ovary Syndrome (PCOS)This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
NCT07394530 · Official ClinicalTrials.gov record · Hanoi General Hospital (Vietnam)
RecruitingNot a traditional drug phaseParis
Not a traditional drug phase: Genetic analysis for Polycystic Ovary SyndromeDiagnostic case-control study (1 case for 2 controls). Inclusion of patients with severe insulin resistance syndrome of genetic origin, then inclusion of controls: patients examined for PCOS in day hospital with matching age (+/- 5 years) and Body mass index (+/- 5kg/m2).
NCT07412028 · Official ClinicalTrials.gov record · Assistance Publique - Hôpitaux de Paris
RecruitingNot a traditional drug phaseMadrid, Madrid
Not a traditional drug phase: Type 1 diabetes mellitus for Type 1 Diabetes MellitusBACKGROUND Functional ovarian hyperandrogenism, including the polycystic ovary syndrome (PCOS), is very prevalent in women with type 1 diabetes (T1D). The pathogenic mechanisms of this association remain unclear.
NCT07490964 · Official ClinicalTrials.gov record · Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
RecruitingNot a traditional drug phaseGuangzhou, Guangdong
Construction of a Multi-dimensional Risk Assessment System: a Clinical Study of Polycystic Ovary Syndrome C…This watch-and-measure (no experimental treatment required) case-control study aims to develop a multidimensional risk assessment model for thrombophilia-related abnormalities in females with polycystic ovary syndrome (PCOS). The study will analyze endocrine, metabolic, and genetic factors associated with decreased protein C and/or protein S levels in participants with PCOS.
NCT07571096 · Official ClinicalTrials.gov record · Guangdong Women and Children Hospital
RecruitingNot a traditional drug phaseGiza
Not a traditional drug phase: physical exercise program for Polycystic Ovary SyndromeFemales of polycystic ovary syndromes may complain fatty pancreaetic disorder and thyroid hypofunctions (subclinical hypothyroidism)
NCT07591246 · Official ClinicalTrials.gov record · Cairo University
RecruitingPhase 2Shanghai, Shanghai Municipality
Phase 2: testing GLP-1/FGF21 dual agonist (HEC88473) for PCOS (Polycystic Ovary Syndrome)Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine and metabolic disorder among women of reproductive age. It is characterized by oligo-ovulation or anovulation, clinical and/or biochemical hyperandrogenism, and polycystic ovarian morphology.
NCT07616037 · Official ClinicalTrials.gov record · Shanghai Zhongshan Hospital
RecruitingPhase 3Cairo, Cairo Governorate
Phase 3: testing Myo-inositol for Poly Cystic Ovary SyndromeThis study evaluates the how well it works of alpha-lipoic acid combined with myo-inositol, with or without metformin, in improving menstrual regularity and ovulation in non-diabetic women with polycystic ovary syndrome (PCOS). The study also assesses metabolic, hormonal, and clinical outcomes.
NCT07630779 · Official ClinicalTrials.gov record · Beni-Suef University
RecruitingNot a traditional drug phaseCairo, Cairo Governorate
Not a traditional drug phase: Diaphragmatic breathing exercises for Polycystic Ovarian Syndrome (PCOS)Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in females in reproductive age and not completely understood. Women with PCOS appear to have an increased frequency of sleep problems.
NCT07698925 · Official ClinicalTrials.gov record · Adly A Adam
RecruitingNot a traditional drug phaseMadison, Wisconsin
Not a traditional drug phase: MRI Visit for PCOSThis study wants to determine how polycystic ovary syndrome (PCOS) impacts overall brain health, such as cerebral blood flow (CBF), brain structure and connectivity, and cognitive performance. 45 reproductive aged (18-45 years) individuals with ovaries, with and without PCOS, will be enrolled to complete brain structure and CBF scans via magnetic resonance imaging (MRI) over 2 testing visits and can expect to be on study for approximately 5 hours over a 1 to 3 month period.
NCT07727512 · Official ClinicalTrials.gov record · University of Wisconsin, Madison
RecruitingNot a traditional drug phaseShanghai, Shanghai Municipality
Not a traditional drug phase: testing oral Fecal Microbiota Transplantation for PCOS (Polycystic Ovary Syndrome)This prospective, two-stage clinical trial aims to measure the safety, preliminary how well it works, and reproductive outcomes of oral Fecal Microbiota Transplantation (FMT) freeze-dried capsules in overweight and obese patients with Polyendocrine Metabolic Ovarian Syndrome (PMOS) undergoing Frozen-Thawed Embryo Transfer (FET).The study is implemented in two sequential phases: Phase Ⅰ (Pilot Exploration): A prospective, open-label, single-arm exploratory study in an initial evaluable cohort (n=11) to evaluate preliminary safety, dynamic gut microbiota colonization, endocrine/metabolic parameters, and pregnancy outcomes following FET. Phase Ⅱ (Confirmatory RCT): A planned multicenter, prospective, randomly assigned controlled trial (RCT) designed to validate the clinical how well it works and underlying mechanisms of oral FMT capsules compared with control interventions, based on findings established in Phase Ⅰ.
NCT07746635 · Official ClinicalTrials.gov record · Shanghai Changzheng Hospital
RecruitingNot a traditional drug phaseAbbottābād, Khyber Pakhtunkhwa
Not a traditional drug phase: testing Orlistat for Polycystic Ovary SyndromeThis randomly assigned controlled clinical trial aims to measure the effect of orlistat on the metabolic and hormonal features of women with polycystic ovary syndrome (PCOS). Eligible women diagnosed with PCOS according to the Rotterdam criteria will be randomly assigned to receive either orlistat plus standard lifestyle advice or dummy treatment (placebo) plus standard lifestyle advice for three months.
NCT07747909 · Official ClinicalTrials.gov record · Khyber Medical University Peshawar
RecruitingNot a traditional drug phaseLos Angeles, California
Not a traditional drug phase: A dietary supplement powder for women for Polycystic Ovarian Syndrome (PCOS)The rationale for this study is to observe the impact of a consumer-grade commercially available product called Milamend Hormone Balance on quality of life and hormonal health in women with self-reported symptoms associated with Polycystic Ovarian Syndrome (PCOS). Additionally, the study aims to observe the impact of the product on menstrual cycle structure and associated symptoms, on reproductive and metabolic markers, on body image concerns, anxiety and general well-being.
NCT07764328 · Official ClinicalTrials.gov record · Mila Mend Inc.
RecruitingNot a traditional drug phaseDiyarbakır, Diyarbakır
Not a traditional drug phase: testing Metformin for PCOS (Polycystic Ovary Syndrome)Polycystic ovary syndrome (PCOS) is a common endocrine disorder frequently associated with obesity, insulin resistance (IR), and metabolic dysfunction. Although lifestyle modification is recommended as first-line therapy, the optimal dietary approach for women with PCOS remains uncertain.
NCT07770711 · Official ClinicalTrials.gov record · Dicle University
RecruitingNot a traditional drug phaseCollege Station, Texas
Not a traditional drug phase: Beef+ for PCOS (Polycystic Ovary Syndrome)This pilot randomly assigned controlled study will plan to enroll 36 adolescent females with Polycystic Ovary Syndrome (PCOS)/Polyendocrine Metabolic Ovarian Syndrome (PMOS) to measure the effectiveness and feasibility of a tailored dietary intervention which will be termed "Beef+", that will emphasize the incorporation of unprocessed, lean beef (\<10% fat) as part of a healthy meal plan to improve glycemic control, diet quality, and health-related quality of life
NCT07780188 · Official ClinicalTrials.gov record · Texas A&M University
RecruitingNot a traditional drug phaseBeijing, Beijing Municipality
Not a traditional drug phase: Model-Guided Precision Acupuncture for Polycystic Ovary SyndromeThis study is designed as a prospective, multicenter, parallel-group randomly assigned controlled trial to measure the effectiveness of a "precision acupuncture + personalized lifestyle" intervention, guided by dynamic multimodal risk monitoring based on the four diagnostic methods of Traditional Chinese Medicine (TCM), in improving insulin resistance in patients with polycystic ovary syndrome (PCOS). Compared with "conventional acupuncture + standard lifestyle intervention," the study will primarily assess changes in the homeostatic model assessment of insulin resistance (HOMA-IR) after 12 weeks of treatment.
NCT07809503 · Official ClinicalTrials.gov record · Peking University Third Hospital
RecruitingNot a traditional drug phaseChicago, Illinois
Not a traditional drug phase: Continuous Positive Airway Pressure (CPAP) for PCOSThe goal of this study is to obtain pilot data investigating the effects of sleep apnea on mitochondrial function and cellular metabolism in Polyendocrine Metabolic Ovarian Syndrome (PMOS) patients.
NCT07871149 · Official ClinicalTrials.gov record · University of Chicago
RecruitingNot a traditional drug phaseIstanbul
Not a traditional drug phase: inositol for Polycystic Ovary Syndrome (PCOS)This study will investigate brown adipose tissue-related physiological responses in women with polycystic ovary syndrome (PCOS). Women with PCOS who have normal body mass index, women with PCOS who are overweight or have obesity, and healthy women will be compared.
NCT07896642 · Official ClinicalTrials.gov record · Istanbul Health and Technology University
RecruitingNot a traditional drug phaseHangzhou, Zhejiang
Not a traditional drug phase: No Intervention: Observational Cohort for Polycystic Ovary Syndrome (PCOS)Introduction : Androgens play a vital role in the female reproductive system, influencing ovarian follicular development, oocyte quality, and ovarian responsiveness to controlled ovarian stimulation. The main circulating androgens include dehydroepiandrosterone sulfate (DHEA-S), dehydroepiandrosterone (DHEA), androstenedione (AD), testosterone (T), and dihydrotestosterone (DHT).
NCT07916909 · Official ClinicalTrials.gov record · Women's Hospital School Of Medicine Zhejiang University
RecruitingNot a traditional drug phaseClermont-Ferrand
Not a traditional drug phase: ovarian drilling by abdominal Laparoscopy for PCOS (Polycystic Ovary Syndrome)Polycystic Ovary Syndrome (PCOS) is a common condition among young women (the leading endocrine disorder) and is responsible for 70% of anovulatory infertility cases. Clinically, it has been defined since 2003 by the Rotterdam criteria, according to the French College of Obstetricians and Gynecologists.
NCT07923552 · Official ClinicalTrials.gov record · University Hospital, Clermont-Ferrand